The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas

David N. Louis, MD

The January 2016 issue of the Journal of Neuropathology and Experimental Neurology features a helpful review article entitled The Diagnostic Use of Immunohistochemical Surrogates for Signature Molecular Genetic Alterations in Gliomas. The review article-- authored by Drs. Jantima Tanboon, Erik A. Williams, and David N. Louis -- summarizes the current experience using immunohistochemistry of glioma samples to identify mutations in IDH1, TP53, ATRX, histone H3 genes, BRAF, EGFR, MGMT, CIC, and FUBP1 as well as guidelines for prudent use of DNA sequencing as a supplemental method. In subsequent posts, I will summarize the key points in this review to make the information easily searchable for readers to use in the future as needed.