The clinicoradiological suspicion in this case of a middle-aged patient with panhypopituitarism was hypophysitis.
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| T1 sagittal post-contrast |
Transphenoidal hypohysectomy yielded the following specimen:
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| Two populations of cells predominate: small monomorphic cells and larger pleomorphic cells |
Immunohistochemistry identified the larger pleomorphic cells as representing a large B-cell lymphoma, while the small cells were intermixed non-neoplastic T-cells.
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| This ACTH immunostain demonstrates the progressive obliteration of the pituitary gland by the invading lymphoma |
Diffuse large B-cell lymphoma presenting as a pituitary mass is rare. A few
case reports exist in the literature.
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