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| TTF-1 immunohistochemistry in the neurohypophysis |
Monday, August 1, 2016
The utility of TTF-1 immunohistochemistry in the diagnosis of sellar region masses
Posterior pituitary cells (pituicytes) manifest nuclear TTF-1 positivity. Anterior pituitary cells are negative. Three rare neurohypophyseal neoplasms which are derived from pituicytes maintain TTF-1 nuclear positivity: pituicytoma, spindle cell oncocytoma, and granular cell tumor. At times when the neuropathologist is trying to distinguish one of these neoplasms from more common sellar tumors -- such as pituitary adenoma, meningioma, and schwannoma -- TTF-1 can be helpful.
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Shannon Curran, MS with her dissection Shannon Curran, a graduate student in the Modern Human Anatomy Program at the University of Co... -
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2 comments:
As a fellow, I got a case diagnosed as a pituitary adenoma but I realized was actually a TTF1 positive lung metastasis. This led to the question of whether the pituitary expressed TTF1. A literature search revealed that TTF1 is called NKX2.1 by basic scientist and is expressed in the neurohypophysis (and that TTF1 knockout leads to agenesis of the lung, thyroid and pituitary). A few IHC stains later, we now know that TTF1 labels neurohyphyseal (and other ventral neuroectodermal) tumors.
Eddie Lee's excellent comment adds another entity to the ddx of TTF1+ sellar tumors that I did not mention: metastasis.
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