Microcystic meningioma in the frontal lobe of a 57-year-old female

When confronted by giant, pleomorphic nuclei among rather non-meningothelial cells, as depicted below, the neuropathologist given a specimen purported to be a benign meningioma might hesitate before agreeing with the neuroradiologist's and neurosurgeon's presumptive diagnosis.

But in this case, a rather small meningotheliomatous component was present to provide reassurance:

A glimpse of a shattered psammoma body also helped to confirm that this was indeed a grade I meningioma, with a predominantly microcystic component.

The microcystic variant is among the most common of the "nonclassical" meningiomas.