I discuss issues pertaining to the practice of neuropathology -- including nervous system tumors, neuroanatomy, neurodegenerative disease, muscle and nerve disorders, ophthalmologic pathology, neuro trivia, neuropathology gossip, job listings and anything else that might be of interest to a blue-collar neuropathologist.
Thursday, August 23, 2018
A case of Alexander disease
Alexander disease is a progressive and often fatal leukodystrophy wherein innumerable Rosenthal fibers form. Caused by mutation in the gene encoding GFAP, Alexander disease can be inherited in an autosomal dominant manner, but typically arises de novo.