This is a case of a 60-year-old female with PCA:
|Although there is diffuse neocortical atrophy, note the prominent occipital lobe atrophy|
|Tau stain of temporal lobe section highlights Alzheimer pathology|
|Pallor of the substantia nigra was noted, and Lewy bodies noted microscopically (see inset)|
|Alpha-synuclein staining showed neocortical Lewy bodies (here in the frontal lobe)|
The final diagnosis was Alzheimer disease and Diffuse Neocortical Lewy Body Disease in the setting of Posterior Cortical Atrophy.