Best Post of November 2016: Calcifying Pseudoneoplasm of the Neuroaxis (CAPNON)

The next in our "Best of the Month" series is from November 11, 2016:

Approximately 59 cases of CAPNON have been reported in the literature, A non-neoplastic entity that can be found in either an intra-axial or extra-axial location, the pathogenesis of CAPNON is unclear but a reactive process has been favored. The outcome is generally considered to be excellent, with gross total resection typically curative. This case is somewhat unique in that it harbors adipose tissue.

Foci of calcification and fat are present in this midline example

Nodules of basophilic calcification

The calcifications have a chondromyxoid appearance

Surgery was complicated as the lesion encased the anterior cerebral arteries

References:

Aiken AH, Akgun H, Tihan T, Barbaro N, Glastonbury C. Calcifying pseudoneoplasms of the neuroaxis: CT, MR Imaging, and Histologic Features. American Journal of Neuroradiology 30 (2009) 1256-1260.

Duque SG, Lopez DM, de Mendivil AO, Fernandez JD. Calcifying pseudoneoplasms of the neuroaxis: Report of four cases and review of the literature. Clinical Neurology and Neurosurgery 143 (2016) 116-120.

Calcifying Pseudoneoplasm of the Neuroaxis (CAPNON)

Approximately 59 cases of CAPNON have been reported in the literature, A non-neoplastic entity that can be found in either an intra-axial or extra-axial location, the pathogenesis of CAPNON is unclear but a reactive process has been favored. The outcome is generally considered to be excellent, with gross total resection typically curative. This case is somewhat unique in that it harbors adipose tissue.

Foci of calcification and fat are present in this midline example

Nodules of basophilic calcification

The calcifications have a chondromyxoid appearance

Surgery was complicated as the lesion encased the anterior cerebral arteries

References:

Aiken AH, Akgun H, Tihan T, Barbaro N, Glastonbury C. Calcifying pseudoneoplasms of the neuroaxis: CT, MR Imaging, and Histologic Features. American Journal of Neuroradiology 30 (2009) 1256-1260.

Duque SG, Lopez DM, de Mendivil AO, Fernandez JD. Calcifying pseudoneoplasms of the neuroaxis: Report of four cases and review of the literature. Clinical Neurology and Neurosurgery 143 (2016) 116-120.