Wednesday, September 4, 2019

Best Post of May 2019: Helpful Glossary of Pathology Terms

The next in our "Best of the Month" series is from May 9, 2019:

Thursday, August 29, 2019

Inova Neuropathology and Neuroradiology Course Takes Place January 13-17, 2020

Hsiang-Chih (Sean) Lu, MD, PhD
Dr. Hsiang-Chih (Sean) Lu, MD, PhD, neuropathology fellow at Washington University in St. Louis, writes the following:

"There is an annual neuroradiology and neuropathology review course held by Inova. It has a fantastic line-up of speakers but unfortunately it’s not very well known in the pathology field. I thought it may be a good idea to mentioned this on your blog so more people (particularly trainees) know about this course."

A valuable course indeed! Thanks for the reminder, Dr. Lu.

Wednesday, August 28, 2019

Dr. Craig Horbinski to deliver webinar entitled "Understanding Molecular Characteristics of Tumors and Implications for Treatment" on September 16

The Society for Neuro-Oncology is initiating a series of webinars as part of it online education effort. To kick off our new webinar series, Dr. Craig Horbinski from Northwestern Medicine/Feinberg School of Medicine will present "Understanding Molecular Characteristics of Tumors and Implications for Treatment" on Monday, September 16, 2019 at 10:00am Central.
Craig Horbinski, MD, PhD

Register for the webinar by clicking here.

Learning objectives
• Explain the importance of advanced molecular testing in the workup of brain tumors • Interpret the results of next-generation sequencing when applied to brain tumors • List the assays, and specific molecular targets, currently recommended for the workup of brain tumors • Discuss the future of methylation profiling on the workup of brain tumors • Allied Health professionals can use the information in educating patients

Target Audience
Allied health professionals, nurses, social workers and therapists in the field of brain tumor research.

Registration is free but limited to the first 500 participants. All SNO webinars will be recorded. If you are unable to participate live, it will be available to view in SNO’s Online Education Center.

Monday, August 26, 2019

Dr. Fausto Rodriguez lectures on pineal tumors live tomorrow on Pathcast

Tuesday, August 27 - 8 AM EST

Topic: Tumors of the Pineal Region
Presented by Fausto Rodriguez, M.D.,
Associate Professor of Pathology, JHUSOM

This seminar can be accessed live
through the following links at 8 AM on Tuesdsay:

For any questions please contact the creators of PathCast, Dr. Rifat Mannan or Dr. Emelio Mardrigal at

To learn more about this and other educational activities from the Department of Pathology visit:

This hour-long PathCast seminar presented by Dr. Fausto Rodriguez will be broadcast live on both Facebook and YouTube.
Live chat will be available for you to discuss the presentation with Dr. Rodriguez during the seminar.

The PathCast will be archived after the live session at:

Monday, August 12, 2019

Best Post of April 2019: Progressive Multifocal Leukoencephalopathy in patients without obvious immunosuppression

The next in our "Best of the Month" series comes from Friday, April 12, 2019:

I recently received a case in consultation which turned out to be progressive multifocal leukoencephalopathy (PML). Reading the clinical history, it was not entirely clear what predisposed the patient to PML. It wasn't clear, that is, until my mentor (the illustrious BK DeMasters) referred me to a nine-year-old paper by Sarah Gheuens, Gerald Pierone, Patrick Peeters, and Igor J. Koralnik entitled Progressive Multifocal Leukoencephalopathy in individuals with minimal or occult immunosuppression (J Neurol Neurosurg Psychiatry2010;81:247-254). In this series, hepatic cirrhosis -- which was what my patient had -- was among the more common conditions in PML patients with minimal immunosuppression. Other conditions that can be associated with PML in the minimally immunosuppressed are those with renal failure and idiopathic CD4+ lymphopenia,

The authors discuss the possible mechanisms for the development of PML in patients with hepatic cirrhosis:

"[H]epatic cirrhosis can lead to portal hypertension and hypersplenism, with subsequent leucopenia as white blood cells are sequestrated in the enlarged spleen. Furthermore, cirrhosis also leads to hypogammaglobulinemia... It is well known that cirrhotic patients have a higher risk of developing bacterial infections, and 30–50% of deaths among cirrhotic patients are directly caused by infections. Immune dysfunction in hepatic disease may be caused by altered cytokine production, impaired cellular immune response and vascular disturbances, which lead together to increased susceptibility to infections."

Tuesday, July 30, 2019

Neuropathology in Tanzania

I spent half the day today at Muhimbili Hospital in Dar es Salaam, Tanzania discussing interesting neuropathology cases with pathology residents. What a privilege to work with such eager and capable residents. We talked about the 2016 WHO CNS tumor classification update and looked at some challenging cases they have a recently encountered.

Wednesday, July 17, 2019

Today is Glioblastoma Awareness Day

Last month, a resolution recognizing today, July 17, as Glioblastoma Awareness Day was passed with unanimous consent in the U.S. Senate – a date on which we honor GBM patients, families, and caregivers, as well as recognize the tireless work of researchers and medical providers. Find out more at "Glioblastoma Awareness Day" 

Friday, July 12, 2019

Best Post of March 2019: Glial cytoplasmic inclusions filling putaminal pencillary fibers in a case of multiple system atrophy (striatonigral type)

The next in our "Best of the Month" series is from Thursday, March 14, 2019, which is simply comprised of a nice representative photomicrograph of an MSA-P case:

Putamen (alpha-synuclein immunohistochemistry)