Friday, November 11, 2016

Calcifying Pseudoneoplasm of the Neuroaxis (CAPNON)

Approximately 59 cases of CAPNON have been reported in the literature, A non-neoplastic entity that can be found in either an intra-axial or extra-axial location, the pathogenesis of CAPNON is unclear but a reactive process has been favored. The outcome is generally considered to be excellent, with gross total resection typically curative. This case is somewhat unique in that it harbors adipose tissue.

Foci of calcification and fat are present in this midline example

Nodules of basophilic calcification

The calcifications have a chondromyxoid appearance

Surgery was complicated as the lesion encased the anterior cerebral arteries

Aiken AH, Akgun H, Tihan T, Barbaro N, Glastonbury C. Calcifying pseudoneoplasms of the neuroaxis: CT, MR Imaging, and Histologic Features. American Journal of Neuroradiology 30 (2009) 1256-1260.

Duque SG, Lopez DM, de Mendivil AO, Fernandez JD. Calcifying pseudoneoplasms of the neuroaxis: Report of four cases and review of the literature. Clinical Neurology and Neurosurgery 143 (2016) 116-120.


Marvin said...

Nice case. Thanks a lot for the pictures! Best, Martin

Beth said...

My 19 yr old daughter has just been diagnosed with CAPNON after presenting with a seizure. 25 doctors later and they are still not sure what course of action to take.'I want them to take a biopsy but they can't all seem to agree as this is the first case they have ever seen. How can I find someone who has treated a patient with CAPNON?