I discuss issues pertaining to the practice of neuropathology -- including nervous system tumors, neuroanatomy, neurodegenerative disease, muscle and nerve disorders, ophthalmologic pathology, neuro trivia, neuropathology gossip, job listings and anything else that might be of interest to a blue-collar neuropathologist.
Monday, October 3, 2016
Mutant IDH1 and thrombosis in gliomas
Craig M. Horbinski, MD PhD
Dr. Craig Horbinski of Northwestern University and colleagues just published a significant paper in Acta Neuropathologica entitled Mutant IDH1 and thrombosis in gliomas. Horbinski's data suggests that, quoting the
abstract, "mutant IDH1 has potent antithrombotic activity within gliomas
and throughout the peripheral circulation. These findings have implications for
the pathologic evaluation of gliomas, the effect of altered isocitrate
metabolism on tumor microenvironment, and risk assessment of glioma patients
for venous thromboemboli." It should be noted that this paper won
the Rubinstein Award at the 2015 American Association of Neuropathologists'
meeting for Best Neuro-Oncology paper.