Best Post of July 2016 -- The signature feature of sparsely granulated growth hormone pituitary adenoma: the fibrous body

The next in our "Best of the Month" series is from July 19, 2016:

The patient is a middle-aged female with subtle signs of acromegaly.

Arrows point to the pale balls in this pituitary adenoma  which correspond to
fibrous bodies on CAM 5.2 immunohistochemistry

The signature feature of sparsely granulated GH adenomas is the finding of widespread, ball-like, cytoplasmic ‘fibrous bodies’ on CAM5.2  in >70% of cells.

CAM 5.2 immunohistochemistry