Thursday, July 25, 2013

What about this cell with red granular cytoplasm?

I'm working on a high-grade glioma and am coming across scattered presumably neoplastic cells that have course red granular cytoplasm. How does one interpret such cells? Does it raise the possibility of a granular cell astrocytoma? Or are these often present and I've just ignored them until now? Thanks for any help you might be able to provide in the comments section!

3 comments:

GH Murdoch Univ Pitt said...

Cells with that type of cytoplasm are not infrequent in anaplastic oligodendrogliomas, Check out Burgers text.
murdoch upmc

Brian E. Moore, MD said...

Thank you, Dr. Murdoch. I'll look that up.....

Brian E. Moore, MD said...

This tumor turned out to be 1p/19q co-deleted. So, my diagnosis of anaplastic oligodendroglioma (prompted in part by Dr. Murdoch's comment) is supported by the molecular result. Thank you Dr. Murdoch!