The next in our "Best of the Month" series is from September 13, 2011:
By consensus, I present to you the five hottest topics in neuropathology today:
1. Chronic Traumatic Encephalopathy - There is an emerging
recognition of CTE among those who have played contact sports. The
elucidation of CTE will continue to have major public health policy
implications.
2. Molecular Subtyping of Brain Tumors - For example,
determination of the presence of O(6)-methylguanine DNA
methyltransferase (MGMT)
activity as a prognosticator of response to alkylating chemotherapy in
gliomas is becoming increasingly important to our clinical
neuro-oncology
colleagues. Other molecular tests that are gaining popularity include
IDH1 and EGFR. Molecular profile panels will become the standard of
practice in the coming decades.
3. Brain Tumor Stem Cells - Questions about their existence and potential as targets for therapy have energized neuro-oncologic research.
4. Role of Microvascular Disease in Expression and Pathogenesis of Alzheimer Disease
- The concept that Alzheimer disease may have a vascular pathogenesis
may radically change the way the disease is prevented and treated.
5. Molecular Developments in Frontotemporal Lobar Degeneration -
As UCSF neurologist Bruce Miller, MD said: "Classification of FTLD is
moving from a syndromic approach toward one based upon neuropathology
and genetics." In particular, the description of the TDP-43
proteinopathies has had a major impact on our understanding of a
previously unrecognized form of dementing disease.
There you have it. Thank you to everyone who contributed to this list. I
think that it will help raise our collective eyes to the horizon.
I discuss issues pertaining to the practice of neuropathology -- including nervous system tumors, neuroanatomy, neurodegenerative disease, muscle and nerve disorders, ophthalmologic pathology, neuro trivia, neuropathology gossip, job listings and anything else that might be of interest to a blue-collar neuropathologist.
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Shannon Curran, MS with her dissection Shannon Curran, a graduate student in the Modern Human Anatomy Program at the University of Co...
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