Wednesday, January 18, 2017

Nice Example of STAT6 nuclear positivity in a WHO grade III Solitary Fibrous Tumor/Hemangiopericytoma

STAT6 immunostaining shows strong nuclear positivity among tumor cells, while the cytoplasm is uniformly negative.  STAT6 nuclear immunoreactivity has been reported as a surrogate marker for the NAB2-STAT6 gene fusion, which is the defining driver mutation of solitary fibrous tumor/hemangiopericytoma. 

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