I discuss issues pertaining to the practice of neuropathology -- including nervous system tumors, neuroanatomy, neurodegenerative disease, muscle and nerve disorders, ophthalmologic pathology, neuro trivia, neuropathology gossip, job listings and anything else that might be of interest to a blue-collar neuropathologist.
Friday, December 2, 2016
Guest Post: Fibrous Bodies Nicely Demonstrated in a Smear from a Somatotroph Pituitary Adenoma
A 30-year-old man presented with bitemporal hemianopsia and
a 3.0 cm pituitary mass was discovered upon MRI. His IGF-1 was elevated to 900,
but he had no signs of acromegaly. A smear of tissue sent for frozen section
evaluation (see below) revealed that most cells had round,
eosinophilic, perinuclear inclusions suggestive of fibrous bodies (some examples are circled). Dot-like
CAM5.2 immunostain (not shown) confirmed my smear-based diagnostic suspicion.