Friday, July 1, 2016

Does IDH1 immunohistochemistry have a slight cross reactivity with IDH2 mutation?

IDH1 immunohistochemistry

This WHO grade II oligodendroglioma had a slight blush of positivity for IDH1. Subsequent mutational analysis revealed an IDH2 mutation. It makes you wonder whether there is a slight cross reactivity of the immunohistochemical stain for IDH2 mutation. Anyone else have this experience?
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