We were sent this case in consultation to rule out infiltrating neoplasm. The diagnosis is amyloid beta related angiitis (ABRA). In this case, no infarction was present in the specimen, but white matter rarefaction (the presumed pathologic correlate to the
leukoaraiosis reported on imaging) is present.
 |
| Granulomatous vasculitis associated with pink hyaline material in vessel
walls |
 |
The
pink hyaline material is shown to be beta-amyloid by immunohistochemistry
|
 |
| White matter rarefaction (upper half of picture) correlating with leukoaraiosis seen on imaging |
1 comment:
Had a case of this in 2006.
Post a Comment