|Gold nanoparticles (yellow) with small interfering RNAs (green) knock down an oncogene in glioblastoma.|
“This is a beautiful marriage of a new technology with the genes of a terrible disease,” said Chad A. Mirkin, a nanomedicine expert and a senior co-author of the study. “Using highly adaptable spherical nucleic acids, we specifically targeted a gene associated with GBM and turned it off in vivo. This proof-of-concept further establishes a broad platform for treating a wide range of diseases, from lung and colon cancers to rheumatoid arthritis and psoriasis.”
Dr. Alexander H. Stegh discovered the Bcl2Like12 oncogene in 2007. "The beauty of the gene we silenced in this study is that it plays many different roles in therapy resistance,." says Stegh. "Taking the gene out of the picture should allow conventional therapies to be more effective.”
Again, thanks to loyal reader and friend, Dr. Doug Shevlin (pictured above on far left with alt country singer Eef Barzelay on far right), for alerting me to this new development in the field of nanotechnogenomics.