Friday, August 16, 2013

What's on your tumor biomarker wish list?

Photo courtesy of Shellie Sherrod
The College of American Pathologists Neuropathology Committee (pictured, minus the illustrious Dr. Aaron Wagner) poses the following question to the neuropathology community worldwide:

"If you were constructing a panel of eight biomarkers there were well-established prognostic/predictive markers for CNS neoplasms, what markers would be included? Note: this is not for diagnosis, but for predicting behavior and should include adult and pediatric brain tumors and can include immunohistochemical and molecular tests."

Thanks in advance for providing your opinion in the comments section.

3 comments:

Anonymous said...

ATRX, p53, IDH1, ki67

Agent 86 said...

1. A surgeon who can hit the lesion
2. Deeper levels (H&E) to find mitoses &/or vascular proliferation
3. Sending the case to a real tumor neuropathologist

See also:
Søland TM, Brusevold IJ. Prognostic molecular markers in cancer - quo vadis?
Histopathology 2013, 63, 297–308. DOI: 10.1111/his.12184

Scout said...

Great reference. Great comment. So true.

I love Agent 86.