A month ago, I posted gross photographs from an autopsy case of mine of a patient with spinocerebellar ataxia type 6. I am now following up with histologic images for this case. The most striking feature was the marked loss of Purkinje cells, which makes sense because SCA6 involves mutation of a calcium channel that is highly expressed on Purkinje neurons:
Many remaining Purkinje neurons demonstrated degenerative changes, including mis-shapened nuclei |
Attenuated cerebellar granule cell layer |
More Purkinje cells in bad shape |
Cerebellar dentate neurons also dengenerated, but not as extensively as Purkinje cells |
Mild involvement of inferior olives. Note the mis-shapen and darkened nuclei of neurons in this location. |
Pons minimally effected, with only occasional degenerating neurons as seen in the center of this photomicrograph next to a normal neuron |
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