Tuesday, September 6, 2011
What are the five hottest topics in neuropathology today?
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Shannon Curran, MS with her dissection Shannon Curran, a graduate student in the Modern Human Anatomy Program at the University of Co... -
Neuropathology Blog has run its course. It's been a fantastic experience authoring this blog over many years. The blog has been a source...
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How about IDH1 in gliomas ?
I agree, Mint, IDH1 should be among the "hot five". Thank you!
Brain tumor stem cells: their existence; how to identify them; their prognostic and predictive importance; their role as potential targets of therapy
I get queries about MGMT every few months, so I would be very interested in others' comments. I tend to discourage it since everyone still seems to get treated with temodar regardless. I was asked about it today in reference to a low grade astrocytoma! So, either I am not following this area as closely as I should be (highly possible), or there is a lot of misunderstanding out there.
Great post, Brian. Reading this kind of stuff makes me so happy I'm a neuropathologist! However, it also fills me with a bit of sadness because I see so few tumors in forensics! I read the old MGMT post and am wondering if you found any ref's for a correlation between EGFR and MGMT?
1--Molecular testing in brain tumors (e.g. MGMT, 1p/19q, EGFR, IDH1, etc.) 2--Traumatic encephalopathy. 3--Teleneuropathology, doing frozens by remote TV link. 4--Biomarkers in Alzheimer's disease, though that straddles the clinical line. 5--Explosion of molecular and genetic details in inherited neuromuscular and pediatric developmental diseases in this century
Thanks for all of the excellent responses! Keep 'em rolling in!
A prominent neuropathologist emailed me this list:
1. Role of microvascular disease in expression & pathogenesis of AD
2. Autophagic dysfunction in both neurodegeneration and neoplasia
3. Role of tumor stem cells in glioma recurrence
4. Molecular subtyping of GBMs & medulloblastoma
To Forensic Pathology: I don't immediately know of any references to EGFR and MGMT correlation, but perhaps someone in our virtual community can help you. Anybody?
Hi. Regarding the MGMT post above, I agree that Temodar and the MGMT test are hot topics. As the wife of a GBM patient, I have specifically requested the MGMT test. If the $600 MGMT test can show that the $10,000 Temodar Rx is ineffective, then why use it? P.S. There is an ezine article on this, which might explain why patients are asking more about it. Hope that helps!
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