Friday, August 27, 2010

Highly pure anti-IDH1 R132H lyophilizates now available - get a free sample

A guest post regarding an important development from Dr. Olaf Bartsch:

The German company Dianova now provides reliable highly pure (goat anti-mouse chromatography) lyophilizates of antibody clone H09. The antibody has been purified from cellculture supernatants by GAM (goat anti-mouse) affinity chromatography resulting in a more intense staining of oligodendroglioma versus a clear negative reaction with glioblastoma.

Dianova's proprietary antibodies are now available in the USA directly and can be ordered from U.S. and Canadian customers on the HistoBioTec website or by purchase order.

Please see the datasheet for details and order a free sample.


Fig.1
Double staining of GFAP (red) and clone H09 (brown) of oligodendrogliopma infiltrating zone demonstrating specific labelling of tumor cells but not GFAP positive reactive astrocytes.










Antibody clone H09 serves as a Tumor Cell Marker for Astrocytoma and Oligodendroglioma and is highly usefull for the differentiation of reactive gliosis from low grade glioma. Moreover, the antibody differentiates single infiltrating tumor cells from reactive gliosis.






Fig.2
Infiltrating zone of anaplastic astrocytoma with specific labelling of infiltrating glioma cells by antibody clone H09.









Clone H09 was developed for staining of standard formalin-fixed paraffin embedded (FFPE) sections in clinical routine and is the first commercially available antibody that specifically stains single cells carrying the IDH1R132H point mutation.


Fig.3
Cortex infiltrated by oligodendroglioma with specific labelling of tumor cells by antibody clone H09.












If you like to discuss any issues regarding application of this unique antibody, you are welcome to visite our booth at the ICN 2010 (XVIIth International Congress of Neuropathology), September 11-15 in Salzburg.

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