(Answer appears as a comment to this post.)
What rare disease is classically characterized by isolated demyelination, or sometimes cystic cavitation, of the corpus callosum?
a. Machado-Joseph disease
b. Marchiafava-Bignami disease
c. Pelezius-Merzbacher disease
d. McCune-Albright syndrome
e. The Miller-Donahue variant of Stoopa disease
1 comment:
The answer is B: Marchiafava-Bignami disease.
The etiology of Marchiafava-Bignami disease is unknown. It was first described in drinkers of Italian red wine, and thought to be due to some toxin in the wine. It has since been observed in drinkers of other types of alcoholic beverages, so that theory no longer holds water. Clinical improvement following treatment with vitamin supplements has led to the current theory that it is due to some kind of vitamin deficiency. (Source: Greenfield’s Neuropathology, 8th edition).
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