tag:blogger.com,1999:blog-54242556382937189152024-03-18T01:10:51.807-05:00neuropathology blogI discuss issues pertaining to the practice of neuropathology -- including nervous system tumors, neuroanatomy, neurodegenerative disease, muscle and nerve disorders, ophthalmologic pathology, neuro trivia, neuropathology gossip, job listings and anything else that might be of interest to a blue-collar neuropathologist.Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.comBlogger899125tag:blogger.com,1999:blog-5424255638293718915.post-63365093443500043342023-03-21T15:22:00.000-05:002023-03-21T15:22:17.497-05:00Dr. Diamandis develops network to help pathologists interface with AI computational scientists<div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEifDQoxBxkYBfiQZ0VADnzrqVp5fZCuJKBU4Kv90Rioy3SlhsarxSKWWYN2RX8wvoIzKD8NTUMaTeDiUCHslcbPEmTxzLFhECpfxs9bo56lYmlW9F7IX7EzvPdNaNDonDZdNuyoA0y80HE8W7bF4DebbsYbMDRRS8HNUl_EeeJudyzhFCZpn8GIdbpMYg/s3376/Screenshot%202023-03-21%20at%207.47.21%20AM.png" style="display: block; padding: 1em 0; text-align: center; "><img alt="" border="0" width="320" data-original-height="1876" data-original-width="3376" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEifDQoxBxkYBfiQZ0VADnzrqVp5fZCuJKBU4Kv90Rioy3SlhsarxSKWWYN2RX8wvoIzKD8NTUMaTeDiUCHslcbPEmTxzLFhECpfxs9bo56lYmlW9F7IX7EzvPdNaNDonDZdNuyoA0y80HE8W7bF4DebbsYbMDRRS8HNUl_EeeJudyzhFCZpn8GIdbpMYg/s320/Screenshot%202023-03-21%20at%207.47.21%20AM.png"/></a></div>
A neuropathology colleague in Toronto (Dr. Phedias Diamandis) is developing some amazing AI-based tools for pathology and academia. He helped recently launch a site called "CODIDO" (https://www.codido.co/) which is a cloud-based network that allows computational scientists to share AI and machine learning algorithms with general users/academics who are keen on using AI but may not know how to code sufficiently well to implement them. It's a great way to allow people to "Demo" code and will hopefully become a central place for pathologists to access a variety of pathology-related algorithms for image analysis projects. They have a few algorithms up already, but they are hoping to expand this by having additional people in the computational pathology space contribute.
If you or your residents are passionate about AI and it's potential in our field but do not have a computational background, his team also recently launched a companion site called "PHARAOH" (pathologyreports.ai) that places histology experts in the driver's seat and allows them to to use their skills to design custom models of intertest and share them with the community. This all can be done without any coding expertise or specialized hardware or software.
Phedias is hoping to develop a snowball effect to populate the tools further to create an inter-active and growing online network of community tools. He shared a relevant lecture decribing these tools in case you want to learn more about the motivation behind both initiatives (https://youtu.be/HaHiCfhMLOU)
Check it out and feel free to contact Dr. Diamandis for more details at p.diamandis@mail.utoronto.ca
Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-47393865641660368032023-01-06T19:44:00.000-06:002023-01-06T19:44:36.537-06:00Neuropathology Blog is backIt's been more than a year since I've posted anything on this site. But, I've thought on and off about reviving the blog. Finally, I have come around to it. So, stay tuned as new posts are coming....
<div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiHlonvN0aoXvzpSjROPu1Mu9B0ZQtysDxKaaZ4qWSDuZ0uQ4b9Ey2cfWpdKzGEBjG3i5tjlPSXG4Ljx3hCuUb68OZtN0CS-2aK2WnS5n6Ui85tan3rKbE4gWjbHAsYItS2kaKCnPsSYTqL1vPyOf3EHbgPDy_fXVjxCA9_BnB1ODVB9UFm1hf5IZAZ-w/s7287/Brian%20E%20Moore.jpg" style="display: block; padding: 1em 0; text-align: center; clear: left; float: left;"><img alt="" border="0" height="320" data-original-height="7287" data-original-width="4860" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiHlonvN0aoXvzpSjROPu1Mu9B0ZQtysDxKaaZ4qWSDuZ0uQ4b9Ey2cfWpdKzGEBjG3i5tjlPSXG4Ljx3hCuUb68OZtN0CS-2aK2WnS5n6Ui85tan3rKbE4gWjbHAsYItS2kaKCnPsSYTqL1vPyOf3EHbgPDy_fXVjxCA9_BnB1ODVB9UFm1hf5IZAZ-w/s320/Brian%20E%20Moore.jpg"/></a></div>Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-1531643753292537082021-09-30T11:02:00.007-05:002021-09-30T11:08:04.217-05:00Brain Pathology's “Under your Microscope” Now UnderwayThis just in from today's guest blogger Dr. Rachael Vaubel:<br>
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Brain Pathology “Under your Microscope” is finally up and running! For anyone unfamiliar, this series is a new Case Image series, which took the place of the Case of the Month.<br>
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This new series presents unusual and interesting “unknown” cases that we come across in daily practice with differential diagnoses and teaching points. The case history is presented along with digital microscopy files allowing the readers to take a first look at the whole scanned slides as they would appear under their microscope. It is a fantastic educational resource for trainees and practicing pathologists. The first cases are published and are available on the <a href="https://onlinelibrary.wiley.com/index/17503639?&startPage=&ContentItemCategory=CASE%20IMAGE"><b>Brain Pathology website</b></a>. The cases are searchable by their diagnosis / author / or other keyword and over time the digital files will provide an archive of clinical teaching cases.<br>
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As before, Under your Microscope encourages the submission of cases from the entire spectrum of neurological disease, including diagnostic challenges, rare clinical entities, cases with classic pathognomonic findings. Please, note: for anyone interested in submitting a case, the submission process for “Under your Microscope” has changed. Cases are now submitted using the same system as other articles for Brain Pathology.<br>
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There is no charge for the publications of Under your Microscope cases. If you had an accepted case prior to 2020, which remains unpublished, please contact Caterina Giannini (Giannini.Caterina@mayo.edu).Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-51081881477047094602021-09-03T12:35:00.003-05:002021-09-03T12:35:54.284-05:00Webinar in Quantitative Digital Pathology Methods Applied to NeuropathologyDr. Maggie Flanagan of Northwestern University recently informed me of the upcoming digital pathology webinar session which Dr. Pete Nelson will be leading this month. Here are the details:
Quantitative Digital Pathology Methods Applied to Neuropathology
Monday, September 13, 2021 at 11:00am ET
The ADRC Digital Pathology Working Group in collaboration with NACC invite you to attend a one-hour webinar session which will provide an overview on developing and understanding questions in science that can be answered using digital neuropathology.
SPEAKERS
Peter T. Nelson, MD, PhD - Professor of Pathology; Director of Neuropathology; ADRC Neuropathology Core Leader, University of Kentucky ADRC
Brittany N. Dugger, PhD - Assistant Professor of Pathology and Laboratory Medicine; ADRC Neuropathology Co-Core Leader at UC Davis ADRC; Co-Leader UC Davis School of Medicine Machine Learning Working Group
Melissa E. Murray, PhD - Associate Professor of Neuroscience; ADRC Neuropathology Co-Core Leader at Mayo Clinic ADRC
John F. Crary, MD, PhD - Professor of Pathology, Molecular and Cell Based Medicine, and Neuroscience; Director of Neuropathology Brain Bank and Research Core; Co-Director of ADRC Neuropathology Core at Mount Sinai ADRC
Register to Attend
In order to receive the Zoom link for this free webinar on Monday, September 13th, you must <a href="https://go.naccdata.org/digital-pathology-webinar-sept-13?utm_campaign=Digital%20Pathology%20Webinar&utm_medium=email&_hsmi=152503777&_hsenc=p2ANqtz--R3OjkKyXK1IUkWx93xA7mYAPuxANDJGB20X96Shyey9F-4pgLkxozrBcmAuusdgVeh9bR_L9qF0chjopyJJafX4jDvWxtWWgoUw7smozUNnul5qw&utm_content=152503777&utm_source=hs_automation"><b>register here<i></i></b></a>. Upon registering, you will receive a follow-up email with the Zoom link and Calendar Invite, as well as automatic reminders about the event with timely and necessary information.
Contact for further questions: naccmail@uw.edu.Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-66174800986397298722021-06-09T13:51:00.000-05:002021-06-09T13:51:33.037-05:00Forensic Neuropathology Symposium kicks off 97th Annual AANP MeetingDr. Marc Del Bigio of the University of Manitoba was first in the line-up for an excellent forensic neuropathology symposium as a satellite preface to the 97th Annual Meeting of the American Association of Neuropathologists. His discussion was entitled "Chronic Traumatic Encephalopathy Outside of the Sports Arena". After a review of the history of the development of CTE as a diagnostic entity, Dr. Del Bigio discussed the fact that this disease does not only occur among athletes. Dr. Del Bigio studied 111 brains in a routine autopsy service of patients aged 18 to 60 years old. Del Bigio and his group found that the cases which had CTE pathology had an increased likelihood of having a clinical history of repeated head trauma and/or substance abuse. Del Bigio suggested that tau immunohistochemistry can be done in a limited way in patients with a clinical history suggestive that CTE is possible. Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-68804208469385456302021-05-10T13:11:00.003-05:002021-05-10T13:11:55.800-05:00Coronavirus does not infect the brain but still inflicts damage, study findsSARS-CoV-2, the virus that causes COVID-19, does not infect brain cells but can inflict significant neurological damage, according to a new autopsy study.
SARS-CoV-2 likely does not directly infect the brain but can still inflict significant neurological damage, according to <a href="https://www.sciencedaily.com/releases/2021/04/210416120044.htm">a new study</a> from researchers at Columbia University Vagelos College of Physicians and Surgeons.
"There's been considerable debate about whether this virus infects the brain, but we were unable to find any signs of virus inside brain cells of more than 40 COVID-19 patients," says James E. Goldman, MD, PhD, professor of pathology and a leading author of the study.
The study, published in the journal Brain, is the largest and most detailed COVID-19 brain autopsy report published to date, suggests that the neurological changes often seen in these patients may result from inflammation triggered by the virus in other parts of the body or in the brain's blood vessels.Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-9746957206798846742021-04-02T20:04:00.002-05:002021-04-02T20:04:28.575-05:002021 Update on Meningeal Solitary Fibrous TumorMeningeal Solitary Fibrous Tumor (SFT) is an uncommon tumor, accounting for less than 1% of CNS tumors. It is a fibroblastic neoplasm with a genomic inversion at the 12q13 locus, leading to NAB2-STAT6 gene fusion and surrogate nuclear STAT6 immunohistochemical expression. SFT generally affects adults in the fifth to seventh decades. It is dural-based and typically supratentorial, but 10% have a spinal location. SFT has a high propensity for recurrence and metstasis, at times occuring decades after initial diagnosis. Imaging often prompts a pre-operative assumption of meningioma as the diagnosis. Histologically, the tumor has a spindle cell appearance and variably cellular with abundant stromal keloid-type collagen. Some examples are very cellular tumors with densely packed round-to ovoid cells and little intervening stroma. Mitoses and necrosis can be present. Can a true SFT be STAT6 negative on immunohsitochemical examination? Yes, but it is just as likely that the pathologist is looking at something else on the differential diagnosis, including other unusual mesechymal tumors. In such cases, molecular testing for STAT6 fusion is required to render a confident diagnosis.
Grading of SFT has changes since the last iteration of the WHO Classification in 2016. The 2016 criteria depended on the histologic hemangiopericytoma phenotype as a factor in raising this tumor from a grade I up to a grade II tumor. Now, in the soon-to-be-released 2021 WHO Classification, this phenotype is not considered important -- with emphasis instead on mitotic count as a means of creating grading cut-offs. Specifically, SFTs with fewer than 5 mitoses per ten high-power fields are considered grade 1, while a mitotic count of 5 or greater justifies a grade 2 designation. If, in addition to this elevated mitotic count, necrosis is present, then a grade 3 designation is assigned.
There have been reported some rare pattern in SFT, including lipomatous, pappillary, giant cell, and myxoid; but these do not affect prognosis. If STAT6 is negative, the pathologist shoud think about other entities in the differential diagnosis, including fibrous meningioma, a variety of mesenchymal tumors (such as phosphaturic mesenchymal tumor), malignant peripheral nerve sheath tumor, and primary non-pigmented melanocytic tumors of the CNS.
To reiterate, three grade of SFT will be recognized in the 2021 WHO classification of CNS tumors:
Grade 1 - SFT with less than five mitotic figures per ten high power fields;
Grade 2 - SFT with five or greater mitotic figures per ten high power fields;
Grade 3 - SFT with five or greater mitotic figures per ten high power fields and necrosis.
This information is taken from an excellent lecture on this SFTs delivered by Dr. Caterina Giannini at this year's annual USCAP meeting (see photo of her below delivering her lecture remotely). Thanks Dr. Gianinni for distilling this topic down to a concoction suitable for us blue-collar neuropathologists to imbibe!
<div class="separator" style="clear: both;"><a href="https://1.bp.blogspot.com/-TYlOhGqsdck/YGd4IEFyEzI/AAAAAAAADwM/1dEY7kDx--U0XLY_KRU6owDmuOcdU8JHQCLcBGAsYHQ/s999/Giannini%2Blecturing.png" style="display: block; padding: 1em 0; text-align: center; "><img alt="" border="0" width="320" data-original-height="562" data-original-width="999" src="https://1.bp.blogspot.com/-TYlOhGqsdck/YGd4IEFyEzI/AAAAAAAADwM/1dEY7kDx--U0XLY_KRU6owDmuOcdU8JHQCLcBGAsYHQ/s320/Giannini%2Blecturing.png"/></a></div>
Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-50842890078578763442021-03-15T09:08:00.003-05:002021-03-15T09:17:21.181-05:00Glioma diagnostics and research in JoVEI recently received an email from Chun-Chieh (Paul) Lin and George Zanazzi at Dartmouth-Hitchcock Medical Center. They were invited as editors for a new Methods Collection in JoVE focusing on "<a href="https://www.jove.com/methods-collections/910/glioma-diagnostics-and-research">Glioma diagnostics and research</a>". Dr. Lin and Zanazzi write: "We intend to highlight techniques used in the diagnostic classification of glial neoplasms and also in vivo or in vitro glioma research models. We welcome a variety of submissions covering these challenging but interesting neoplasms." Please feel free to contact Paul (Chun-Chieh.Lin@hitchcock.org) and George (George.J.Zanazzi@hitchcock.org) for details!
<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="https://1.bp.blogspot.com/-m5jAZUUS0dU/YE9r48nYGsI/AAAAAAAADuo/4Zt6aRny05AcAmY7KVOau7usCkmvzqqOACLcBGAsYHQ/s270/1352.png" style="display: block; margin-left: auto; margin-right: auto; padding: 1em 0px; text-align: center;"><img alt="" border="0" data-original-height="270" data-original-width="180" height="320" src="https://1.bp.blogspot.com/-m5jAZUUS0dU/YE9r48nYGsI/AAAAAAAADuo/4Zt6aRny05AcAmY7KVOau7usCkmvzqqOACLcBGAsYHQ/s320/1352.png" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Dr. Paul Lin</td></tr></tbody></table><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="https://1.bp.blogspot.com/-FzwGkQH_NWA/YE9r47wU2GI/AAAAAAAADus/o8kotynY67Ev3TxPg4nR2h8K5JwF5cIVwCLcBGAsYHQ/s270/1353.png" style="display: block; margin-left: auto; margin-right: auto; padding: 1em 0px; text-align: center;"><img alt="" border="0" data-original-height="270" data-original-width="180" height="320" src="https://1.bp.blogspot.com/-FzwGkQH_NWA/YE9r47wU2GI/AAAAAAAADus/o8kotynY67Ev3TxPg4nR2h8K5JwF5cIVwCLcBGAsYHQ/s320/1353.png" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Dr. George Zanazzi</td></tr></tbody></table>Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-11394585428080257682021-03-01T13:41:00.036-06:002021-03-02T13:18:57.563-06:00Dr. Mauro C. Dal Canto (January 1, 1944 – December 16, 2020)<p>I recently received word from Dr. Eddie Lee of the passing of Dr. Mauro Dal Canto due to a tragic aircraft accident.</p><p><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: right; margin-left: 1em; text-align: right;"><tbody><tr><td style="text-align: center;"><a href="https://lh3.googleusercontent.com/-VUajpCGuUDo/YDlQqIK2_1I/AAAAAAAADuM/uMP4tExB3aEPqatyReqQP2gPpzMdCzShwCLcBGAsYHQ/download.jpg" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img alt="" data-original-height="225" data-original-width="224" height="240" src="https://lh3.googleusercontent.com/-VUajpCGuUDo/YDlQqIK2_1I/AAAAAAAADuM/uMP4tExB3aEPqatyReqQP2gPpzMdCzShwCLcBGAsYHQ/download.jpg" width="239" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;"><span style="text-align: left;">Dr. Maura Dal Canto</span></td></tr></tbody></table><br />Dr. Dal Canto was a neuropathologist at Northwestern for many years and a member of the American Association of Neuropathologists as well. Here is <a href="https://www.parkrecord.com/news/obituaries/obituary-for-dr-mauro-c-dal-canto/" target="_blank">Dr. Canto's obituary</a>. </p><p><br /></p>Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-70674608360494536492021-02-26T13:36:00.004-06:002021-02-26T13:36:42.087-06:00History and Overview of Digital Pathology Webinar Scheduled for Monday, March 8<p><span style="background-color: white; color: #201f1e; font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 15px;">I recently received notification from <a href="https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=46069" target="_blank">Margaret E. Flanagan, M.D.</a>, assistant professor of pathology at Northwestern, about an upcoming event featuring several well-known neuropathologists. You can register for the event <a href="https://www.eventbrite.com/e/history-overview-of-digital-pathology-webinar-tickets-141895536369" target="_blank">here</a>. Thanks very much, Dr. Flanagan!</span></p><p><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody><tr><td style="text-align: center;"><a href="https://lh3.googleusercontent.com/-WVuj9qCIrP0/YDlNcS42RbI/AAAAAAAADuE/TOinvDEv62cMt3YS5XbNR5tzOPjs5XECgCLcBGAsYHQ/46069.jpg" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img alt="" data-original-height="188" data-original-width="160" height="240" src="https://lh3.googleusercontent.com/-WVuj9qCIrP0/YDlNcS42RbI/AAAAAAAADuE/TOinvDEv62cMt3YS5XbNR5tzOPjs5XECgCLcBGAsYHQ/46069.jpg" width="204" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Dr. Margaret E. Flanagan</td></tr></tbody></table><span style="background-color: white; color: #201f1e; font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 15px;"><br /><br /></span></p><p align="center" style="color: #201f1e; font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px; text-align: center;"><br /></p><p align="center" style="color: #201f1e; font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px; text-align: center;"> </p><div align="center" style="border: 0px; color: #201f1e; font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 15px; font-stretch: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; min-width: 100%; width: 600px;"><tbody><tr><td style="background-color: #005394; width: 600px;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; min-width: 100%; width: 600px;"><tbody><tr><td style="padding: 7.5pt 15pt;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p align="center" style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px; text-align: center;"><b><i><span style="border: 0px; color: white; font-family: Georgia, serif; font-size: 14.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">History & Overview of Digital Pathology</span></i></b><b><span style="border: 0px; color: #717a80; font-family: Arial, sans-serif; font-size: 18pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></b></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p align="center" style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px; text-align: center;"><b><i><span style="border: 0px; color: white; font-family: Tahoma, sans-serif; font-size: 14.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></i></b><b><i><span style="border: 0px; color: white; font-family: Georgia, serif; font-size: 14.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><span class="x_markjh62vil6p" style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Webinar</span><span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span>- March 8, 2021</span></i></b><b><span style="border: 0px; color: #717a80; font-family: Arial, sans-serif; font-size: 18pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></b></p></div></div></div></td></tr></tbody></table></div></td></tr></tbody></table></div><p align="center" style="color: #201f1e; font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px; text-align: center;"> </p><div align="center" style="border: 0px; color: #201f1e; font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 15px; font-stretch: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; min-width: 100%; width: 600px;"><tbody><tr><td style="width: 600px;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; width: 600px;"><tbody><tr><td><div align="center" style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; width: 600px;"><tbody><tr style="height: 0.75pt;"><td style="height: 0.75pt; padding: 0px 0px 7.5pt; width: 600px;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p align="center" style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px; text-align: center;"></p></div></td></tr></tbody></table></div></td></tr></tbody></table></div></td></tr></tbody></table></div><p align="center" style="color: #201f1e; font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px; text-align: center;"> </p><div align="center" style="border: 0px; color: #201f1e; font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 15px; font-stretch: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; min-width: 100%; width: 600px;"><tbody><tr><td style="width: 600px;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; min-width: 100%; width: 600px;"><tbody><tr><td style="padding: 7.5pt 15pt;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #222222; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">The ADRC Digital Pathology Working Group and National Alzheimer's Coordinating Center are excited to host the following<span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span><span class="x_markjh62vil6p" style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">webinar</span><span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span>on Monday, March 8, 2021 at 11am ET/ 8am PT!</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><b><i><span style="border: 0px; color: #cf8f12; font-family: inherit; font-size: 13.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">History and Overview of Digital Pathology</span></i></b><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Join us on March 8th as we kick off our 2021 Digital Pathology<span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span><span class="x_markjh62vil6p" style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Webinar</span><span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span>Series with our first event: History and Overview of Digital Pathology<span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span><span class="x_markjh62vil6p" style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Webinar</span>. This one-hour<span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span><span class="x_markjh62vil6p" style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">webinar</span><span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span>session will provide an introduction and overview of digital pathology. The speaker and panelists are outlined below.</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><b><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Speaker:</span></b><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Charles L. White, III MD</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><b><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Panelists:</span></b><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Charles L. White III MD</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Sandra Camelo-Piragua, MD</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">C. Dirk Keene, MD, PhD</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Peter T. Nelson, MD, PhD</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Jeanelle Azira Torres</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Brittany N. Dugger, PhD</span></p></div></div></div></td></tr></tbody></table></div></td></tr></tbody></table></div><div align="center" style="border: 0px; color: #201f1e; font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 15px; font-stretch: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; min-width: 100%; width: 600px;"><tbody><tr><td style="width: 600px;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; min-width: 100%; width: 600px;"><tbody><tr><td style="padding: 7.5pt 15pt;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #222222; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Have questions you want to ask our panelists? Submit them in advance to </span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><a data-auth="NotApplicable" href="mailto:naccmail@uw.edu" rel="noopener noreferrer" style="border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="_blank"><b><span style="border: 0px; color: #3661bd; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">naccmail@uw.edu</span></b></a></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><b><i><span style="border: 0px; color: #cf8f12; font-family: inherit; font-size: 13.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">About the 2021 Digital Pathology<span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span><span class="x_markjh62vil6p" style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Webinar</span><span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span>Series</span></i></b><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">At 11am ET on the second Monday of each month*, keep an eye out for our Digital Pathology<span style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span><span class="x_markjh62vil6p" style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Webinar</span>s, showcasing 30 minutes of panel discussion and 30 minutes of Q&A.</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #1a191a; font-family: inherit; font-size: 12pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;">Topics include an overview of digital pathology, slide scanner purchasing considerations, HALO Software Applications, Aperio Software Applications, QuPath Software Applications, Machine Learning for Digital Pathology and general troubleshooting.</span><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"></span></p></div><div style="border: 0px; color: inherit; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><p style="font-family: Calibri, sans-serif; font-size: 11pt; margin: 0px;"><span style="border: 0px; color: #403f42; font-family: inherit; font-size: 10.5pt; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"> </span></p></div></div></div></td></tr></tbody></table></div></td></tr></tbody></table></div><div align="center" style="border: 0px; color: #201f1e; font-family: Calibri, Arial, Helvetica, sans-serif; font-size: 15px; font-stretch: inherit; font-variant-east-asian: inherit; font-variant-numeric: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><table style="border-collapse: collapse; font: inherit; min-width: 100%; width: 600px;"><tbody></tbody></table></div>Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-61075881809091931872021-02-04T09:12:00.003-06:002021-02-04T09:12:50.237-06:00Dr. William Yong of UC Irvine co-authors timely update of neuro-COVID<p> <span face="Calibri, sans-serif" style="background-color: white; color: #201f1e; font-size: 11pt;">I recently received an email from the illustrious <a href="https://www.linkedin.com/in/william-yong-603865ba" target="_blank">William Yong, MD</a> at UC Irvine Health. He alerted me to an excellent article which he co-authored entitled <a href="https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2993" target="_blank">Neuropathology of COVID-19 (neuro-COVID): Clinicopathological Update</a>. Dr. Yong writes: "</span><span style="background-color: white; color: #201f1e; font-family: Calibri, sans-serif; font-size: 11pt;">I don’t normally forward my pubicationss but will do so for this COVID Neuropath review (reviewed over 180 cases from the literature) since things move fast with COVID literature and as Free Neuropathology is a new journal and not in Pubmed yet. The paper will eventually get into Pubmed as its is NIH funded but process is slower. </span><span style="background-color: white; color: #201f1e; font-family: Calibri, sans-serif; font-size: 11pt;">The article is open access and free to download at Free Neuropathology. If you think it will be of some value to your readers, please feel free to share in your wonderful blog." A </span><span style="background-color: white; color: #201f1e; font-family: Calibri, sans-serif; font-size: 11pt;">PDF version is available here </span><a data-auth="NotApplicable" href="https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2993/3173" rel="noopener noreferrer" style="background-color: white; border: 0px; font: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" target="_blank">https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2993/3173</a></p><p>Thanks very much, Dr. Yong, for alerting us to this timely update!</p>Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-79896028545749501792020-10-06T12:30:00.000-05:002020-10-06T12:30:21.986-05:00There is no right career path: A perspective from an immigrant physician-scientist and neuropathologist<p><span style="background-color: white; color: #201f1e; font-family: Tahoma; font-size: 13px;">Subhojit Roy, MD, PhD recently wrote an interesting post on his journey as a immigrant physician-scientist in the United States. <a href="http://crosstalk.cell.com/blog/there-is-no-right-career-path-a-perspective-from-an-immigrant-physician-scientist" target="_blank">Here's the link</a>. His conclusion:</span></p><p>"<span data-contrast="auto" style="background-color: white; box-sizing: border-box; color: #333333; font-family: Helvetica, Arial, sans-serif; font-size: 14.95px; letter-spacing: 0.1495px; margin: 0px;"><span style="background-color: inherit; box-sizing: border-box; margin: 0px;">Some amount of foresight and planning is obviously important for success in any field. But most successful careers do not follow<span style="box-sizing: border-box;"> </span></span></span><span data-contrast="auto" style="background-color: white; box-sizing: border-box; color: #333333; font-family: Helvetica, Arial, sans-serif; font-size: 14.95px; letter-spacing: 0.1495px; margin: 0px;"><span style="background-color: inherit; box-sizing: border-box; margin: 0px;">a<span style="box-sizing: border-box;"> </span></span></span><span data-contrast="auto" style="background-color: white; box-sizing: border-box; color: #333333; font-family: Helvetica, Arial, sans-serif; font-size: 14.95px; letter-spacing: 0.1495px; margin: 0px;"><span style="background-color: inherit; box-sizing: border-box; margin: 0px;">prescribed trajector</span></span><span data-contrast="auto" style="background-color: white; box-sizing: border-box; color: #333333; font-family: Helvetica, Arial, sans-serif; font-size: 14.95px; letter-spacing: 0.1495px; margin: 0px;"><span style="background-color: inherit; box-sizing: border-box; margin: 0px;">y. It’</span></span><span data-contrast="auto" style="background-color: white; box-sizing: border-box; color: #333333; font-family: Helvetica, Arial, sans-serif; font-size: 14.95px; letter-spacing: 0.1495px; margin: 0px;"><span style="background-color: inherit; box-sizing: border-box; margin: 0px;">s debatable whether meticulous career forecasting and vetting is any better than planning for the future in broad strokes, leaving some things to chance, and believing that one always has the power to make a change. Life is an exploration, not a Cuneiform tablet. And there is no such thing as the right career path."</span></span></p>Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-71395925057466929302020-06-04T13:28:00.000-05:002020-06-04T13:28:50.723-05:00Brain Pathology and the International Society of Neuropathology have established Twitter accountsFor readers wanting updates on the latest developments in neuropathology via social media, I recommend two Twitter accounts:<br />
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<a href="https://twitter.com/brainpathol">Brian Pathology</a><br />
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<a href="https://twitter.com/IntSocNeuropath">International Society of Neuropathology (ISN)</a><br />
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Among recent tweets were a link to a minisymposium on the molecular pathogenesis of prion diseases (Brain Pathology) and the latest news about the upcoming AANP meeting (ISN).Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-51706439813938749152020-04-14T14:33:00.001-05:002020-04-14T14:33:42.614-05:00J. Hume Adams has passed away<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
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<tr><td class="tr-caption" style="text-align: center;">J. Hume Adams in 1972</td></tr>
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J. Hume Adams, Professor of Neuropathology in Glasgow, has died. With David Graham, Adams edited the fourth and fifth editions of Greenfield's Neuropathology. During his career, Adams made great advances in the study of neurotrauma.Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-47172495599449135442020-04-05T09:54:00.001-05:002020-04-06T10:45:47.965-05:00Neuropathologist Matija Snuderl featured in major journal discussing the use of artificial intelligence in cancer diagnostics<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: right; margin-left: 1em; text-align: right;"><tbody>
<tr><td style="text-align: center;"><a href="http://3.bp.blogspot.com/-wmkOLcldoqM/XotObia7DAI/AAAAAAAADrE/TXNgRD1h3TwkzxBqYoca8f99OXEnB15-wCK4BGAYYCw/s1600/yearinreview-2018-neurosurgery-matija-snuderl.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" height="213" src="https://3.bp.blogspot.com/-wmkOLcldoqM/XotObia7DAI/AAAAAAAADrE/TXNgRD1h3TwkzxBqYoca8f99OXEnB15-wCK4BGAYYCw/s320/yearinreview-2018-neurosurgery-matija-snuderl.jpg" width="320" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Matija Snuderl, MD</td></tr>
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<a href="https://nyulangone.org/doctors/1497881254/matija-snuderl"><span style="color: red;">Dr. Matija Snuderl</span></a>, neuropathologist and molecular pathologist at <a href="https://nyulangone.org/"><span style="color: red;">New York University Langone Health</span></a>, was featured in <a href="https://www.nature.com/articles/d41586-020-00847-2"><span style="color: red;">a recent article appearing in <i>Nature</i></span></a> (March 26, 2020, Vol 579, p S14-S16). The article, which addresses the use of artificial intelligence (AI) in cancer diagnostics, opens with Dr. Snuderl experiencing a moment that many of us neuropathologists have had wherein we hesitate before signing out a case because of a feeling that something might be just a bit different about a particular specimen. That feeling prompts us to do something else (run more ancillary testing, get a consult, sleep on it and take another look the next day, etc.). In Dr. Snuderl's case, he was looking at a case which was thought to be a recurrence of a medulloblastoma in a young girl. Some of the histologic features didn't quite fit with medulloblastoma. "So, to help him make up his mind, Snuderl turned to a computer. He arranged for the girl to have a full-genome methylation analysis," writes Neil Savage, author of the article. Snuderl relays the result of this investigation: "The tumor came back as a glioblastoma... If I had finalized the case just on pathology, I would have been terribly wrong." The AI system Snuderl used involved a database of thousands of tumor methylation profiles at the German Cancer Research Center. NYU Langone's <a href="https://nyulangone.org/locations/perlmutter-cancer-center"><span style="color: red;">Perlmutter Cancer Center</span></a> is applying AI to the classification of tumors of all sorts, not only using pathologic samples, but also MR imaging, mammograms, and other means of diagnosis.<br />
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Thanks to Dr Snuderl for representing the important role neuropathologists play in cancer diagnostics in the age of molecular medicine and article intelligence. Thanks also to <a href="https://neuropathologyblog.blogspot.com/search?q=Lawlor"><span style="color: red;">Dr. Michael Lawlor</span></a>, of the Medical College of Wisconsin, for alerting me to this article!Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-50881351629263580682020-03-25T11:06:00.000-05:002020-03-25T11:06:06.074-05:00Lost Smell and Taste Hint COVID-19 Can Target the Nervous System<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="http://3.bp.blogspot.com/-71njK94J2AY/Xnt_8l4jGYI/AAAAAAAADqg/lzzC8ImtdNISCZ8XG7PA_mkgEvJQsnivACK4BGAYYCw/s1600/MAnderson.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" src="https://3.bp.blogspot.com/-71njK94J2AY/Xnt_8l4jGYI/AAAAAAAADqg/lzzC8ImtdNISCZ8XG7PA_mkgEvJQsnivACK4BGAYYCw/s1600/MAnderson.jpg" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Matthew Anderson, MD, PhD</td></tr>
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<a href="https://www.bidmc.org/research/research-by-department/neurology/laboratories/matthew-anderson-laboratory"><span style="color: red;">Dr. Matt Anderson</span></a>, chief of neuropathology at Beth Israel in Boston, forwarded me a <span style="color: red;"><a href="https://www.the-scientist.com/news-opinion/lost-smell-and-taste-hint-covid-19-can-target-the-nervous-system-67312"><span style="color: red;">recent article from <i>The Scientist</i></span></a>. </span>The article describes the experience of <span style="color: red;">Alessandro Laurenzi</span>, a biologist working in Bologna, Italy, regarding the proposition that COVID-19 infected patients can have transient loss of the sense of smell. Olfactory sensory loss may play a role in early diagnosis, but it may also help in understanding pathogensis.<br />
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Dr. Anderson is quoted in the article, stating that central nervous system involvement by the virus may play a part in the respiratory symptomatology.<br />
<br />Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-6963791997017387332020-03-23T16:22:00.000-05:002020-03-23T16:22:14.231-05:00George Perry, former AANP president, granted meritorious award by the American Society for Investigative Pathology<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody>
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<tr><td class="tr-caption" style="text-align: center;">George Perry, PhD</td></tr>
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It was recently announced that <span style="color: red;"><a href="https://www.utsa.edu/biology/faculty/GeorgePerry.html"><span style="color: red;">Dr. George Perry</span></a> </span>has been given the Rous-Whipple Award by the American Society for Investigative Pathology. According to the <a href="https://www.asip.org/membership-community/awards-honors/meritorious-awards/rous-whipple-award/"><span style="color: red;">ASIP website</span></a>, the Rous-Whipple Award "i<span style="background-color: white; font-family: "Work Sans", sans-serif; font-size: 14px;">s presented to a senior scientist with a distinguished career in research who has advanced the understanding of disease and has continued productivity at the time of the award."</span><br />
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<span style="background-color: white; font-family: "Work Sans", sans-serif; font-size: 14px;">Congratulations, Dr. Perry. And thanks to <span style="color: red;"><a href="https://utswmed.org/doctors/charles-white-iii/"><span style="color: red;">Dr. Charles White</span></a> </span>for sharing this news.</span>Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-12160398014628987682020-03-10T10:55:00.000-05:002020-03-10T10:55:37.058-05:00David Solomon and Gregory Fuller garner prestigious awards at USCAP annual meeting<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody>
<tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/-wXkF4grEUBM/Xme1bt4JTII/AAAAAAAADp4/Erju-TAdAswnq0peSLrh-SV8jtTB3xhiQCK4BGAYYCw/s1600/Picture3.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="https://1.bp.blogspot.com/-wXkF4grEUBM/Xme1bt4JTII/AAAAAAAADp4/Erju-TAdAswnq0peSLrh-SV8jtTB3xhiQCK4BGAYYCw/s1600/Picture3.jpg" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">David Solomon, MD, PhD</td></tr>
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<a href="https://profiles.ucsf.edu/david.solomon"><span style="color: red;">Dr. David A. Solomon</span></a>, assistant professor at UCSF, has been awarded the Ramzi S. Cotran Young Investigator Award at the recent annual meeting of the United States & Canadian Academy of Pathology (USCAP) for his work on diciphering the molecular pathogenesis of various brain neoplasms.<br />
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Also at this year's USCAP meeting, <a href="https://faculty.mdanderson.org/profiles/gregory_fuller.html"><span style="color: red;">Gregory N. Fuller, MD, PhD</span></a> was awarded the Harvey Goldman Teaching Award. Among his many contributions to pathology education is authoring the CNS chapter of the latest edition of the textbook <i>Histology for Pathologists</i> (2019).Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-73733285085848631882020-03-05T15:58:00.003-06:002020-03-05T15:58:58.179-06:00Best Post of October 2019: Cytoplasmic Bodies in a Muscle BiopsyThe next in our "Best of the Month" series comes from October 7, 2019:<br />
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The inimitable <a href="https://neuropathologyblog.blogspot.com/2016/12/guest-post-fibrous-bodies-nicely.html" style="color: #888888; text-decoration-line: none;"><span style="color: #e06666;">Dr. Christian Davidson</span></a>, formerly of <a href="http://rwjms.rutgers.edu/" style="color: #888888; text-decoration-line: none;"><span style="color: #e06666;">Robert Wood Johnson Medical School at Rutgers</span></a> and now at the <a href="https://medicine.utah.edu/?utm_source=google&utm_medium=search&utm_campaign=MDrecruitment&campaignid=6664980704&creative=386998619472&gclid=CjwKCAjwxOvsBRAjEiwAuY7L8uSAAieVM7tbd_-N_vParomSAf5JaTCLRVDE-pViS2gi-P-9I2QlyxoCUzMQAvD_BwE" style="color: #888888; text-decoration-line: none;"><span style="color: #e06666;">University of Utah</span></a>, sent in pictures of cytoplasmic bodies in a muscle biopsy from a patient with severe myositis. Thank you, Dr. Davidson!<br /><br /><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="background-attachment: initial; background-clip: initial; background-image: initial; background-origin: initial; background-position: initial; background-repeat: initial; background-size: initial; border: 1px solid rgb(238, 238, 238); box-shadow: rgba(0, 0, 0, 0.1) 1px 1px 5px; color: #222222; margin-left: auto; margin-right: auto; padding: 5px; position: relative; text-align: center;"><tbody>
<tr><td><a href="https://1.bp.blogspot.com/-vp0M2g4Gw7k/XZtK66141eI/AAAAAAAADlA/8Ukd6sPrzD8-L31tNM6YagwbrUTZf7K8ACLcBGAsYHQ/s1600/CytoBodies.tif" imageanchor="1" style="color: #888888; margin-left: auto; margin-right: auto; text-decoration-line: none;"><img border="0" data-original-height="1200" data-original-width="1600" height="300" src="https://1.bp.blogspot.com/-vp0M2g4Gw7k/XZtK66141eI/AAAAAAAADlA/8Ukd6sPrzD8-L31tNM6YagwbrUTZf7K8ACLcBGAsYHQ/s400/CytoBodies.tif" style="background: transparent; border: none; box-shadow: rgba(0, 0, 0, 0.1) 0px 0px 0px; padding: 0px; position: relative;" width="400" /></a></td></tr>
<tr><td class="tr-caption" style="font-size: 10.56px;">Trichrome</td></tr>
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<tr><td class="tr-caption" style="font-size: 10.56px;">Electron Microscopy<br /></td></tr>
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Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-74428448534061749602020-02-06T08:50:00.005-06:002020-02-06T08:55:15.670-06:00Werner Paulus launches freeneuropathology.org<br />
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<tr><td class="tr-caption" style="text-align: center;">Prof. Dr. Werner Paulus</td></tr>
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<span style="color: black; mso-fareast-language: DE;"><a href="https://www.uni-muenster.de/OCCMuenster/members/werner-paulus.html"><span style="color: blue;">Dr. Werner Paulus</span></a> of the <a href="https://www.uni-muenster.de/en/"><span style="color: blue;">University of Munster</span></a>, Germany, recently wrote in to share news of an exciting venture he and his colleagues have just launched:</span></div>
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<span style="color: black; mso-fareast-language: DE;">"After
editing Acta Neuropathologica for 14 years and after founding and editing Acta
Neuropathologica Communications for 5 years, I have stepped down by the end of
2018 as editor of these two journals. A few weeks ago, together with colleagues
from around the world, I have launched <a href="http://freeneuropathology.org/">freeneuropathology.org</a> . This is not
just another neuropath journal, it´s a new type of publishing model without
publisher. The “trick” is that scientists undertake the classical job of the
publisher such as copyediting, layout, promotion, maintenance of the website
etc. This makes the journal more efficient and more flexible, and it makes more
fun because we can design the journal as we like and do not have to follow the
business-driven interests of commercial publishers. It´s entirely free for
readers and for authors (diamond open access). It´s from neuropathologists for
neuropathologists, based on enthusiasm and voluntariness. We are very excited
about this new approach and think that this might be the future of publishing
in general, not only in the field of neuropathology. If you are interested, you
can find more background information on the journal website and in the
inaugural editorial: <span style="color: black;"><a href="https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2610/2480">https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2610/2480</a>"</span><o:p></o:p></span></div>
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<br />Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-58383751211470066762019-12-13T16:02:00.000-06:002019-12-13T16:05:07.185-06:00Blog Job Listings Migrating to AANP Website<a href="http://1.bp.blogspot.com/-hV-kq0NsT0w/XfQJ8iwkHII/AAAAAAAADo0/wxnPh6Q_sRIo_xyFB9HH7egJUbe_LSqSwCK4BGAYYCw/s1600/Picture1.png" imageanchor="1" style="clear: right; float: right; margin-bottom: 1em; margin-left: 1em;"><img border="0" height="282" src="https://1.bp.blogspot.com/-hV-kq0NsT0w/XfQJ8iwkHII/AAAAAAAADo0/wxnPh6Q_sRIo_xyFB9HH7egJUbe_LSqSwCK4BGAYYCw/s320/Picture1.png" width="320" /></a>For the past year or so, the job listings on Neuropathology Blog have been reproduced on the <a href="https://www.neuropath.org/jobs-board"><span style="color: red;">Jobs Board</span></a> of the American Association of Neuropathologists. Rather than continually synchronizing the two lists, I've decided to discontinue the jobs listings on this blog so that candidates have to visit only one site with the most updated listings. Employers can contact the AANP to have a job listing added, subtracted, or modified. Should any institution contact me, I will forward the listing request to the AANP. The fellowship listing has also migrated to the AANP website.<br />
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I wish to publicly thank the inimitable <b>Sherry Miller</b>, wife of <a href="https://www.muhealth.org/doctors/douglas-miller-md-phd"><span style="color: red;">Dr. Doug Miller</span></a>, who originally suggested the idea of having a job listing on this blog. For many years, Sherry played a central role in maintaining the list. The entire neuropathology community has benefited from her work in maintaining the jobs listing. Thank you Sherry!<br />
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Best of luck to all candidates looking for positions in the wonderful field of neuropathology!Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-67347760094595055672019-12-06T11:10:00.000-06:002019-12-06T11:10:12.693-06:00Atypical temporal arteritis<div class="separator" style="clear: both; text-align: center;">
<a href="http://2.bp.blogspot.com/-bafpPVW3oa4/XeqLRhV7CfI/AAAAAAAADoo/SaVpLV3A7SAigNJLx3z0c63Cb6z9-B_WQCK4BGAYYCw/s1600/Picture1.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="320" src="https://2.bp.blogspot.com/-bafpPVW3oa4/XeqLRhV7CfI/AAAAAAAADoo/SaVpLV3A7SAigNJLx3z0c63Cb6z9-B_WQCK4BGAYYCw/s400/Picture1.jpg" width="400" /></a></div>
<br />Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-22055378291699051172019-11-18T14:09:00.000-06:002019-11-18T14:09:04.948-06:00First evidence of immune response targeting brain cells in autism<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody>
<tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/-XMGzwJDlz04/XdL6OEt82oI/AAAAAAAADnM/uSTSzaWinTAx-6HAwXttiswMsTpcBgUmwCK4BGAYYCw/s1600/PhotoHandler.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="https://1.bp.blogspot.com/-XMGzwJDlz04/XdL6OEt82oI/AAAAAAAADnM/uSTSzaWinTAx-6HAwXttiswMsTpcBgUmwCK4BGAYYCw/s400/PhotoHandler.jpg" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Dr. Matt Anderson</td></tr>
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<div style="background-color: white; box-sizing: inherit; color: #1e1e1e; font-family: "Roboto Slab", serif; font-size: 16px; line-height: 1.8; margin-bottom: 1rem; padding: 0px; text-rendering: optimizelegibility;">
<span style="box-sizing: inherit;"><span style="box-sizing: inherit;"><span style="box-sizing: inherit;"><span style="box-sizing: inherit;">In a paper published in </span></span><a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25610" style="background: url("/themes/harvardmedical/images/line-bg.svg") left bottom / calc(100% - 20px) 1px no-repeat; box-sizing: inherit; color: #1e1e1e; cursor: pointer; display: inline; font-weight: 700; line-height: inherit; padding-bottom: 3px; position: relative; text-decoration-line: none; transition: all 0.3s ease 0s;" target="_blank"><em style="box-sizing: inherit; line-height: inherit;"><span style="box-sizing: inherit;"><span style="box-sizing: inherit;">Annals of Neurology</span></span></em></a><span style="box-sizing: inherit;"><span style="box-sizing: inherit;">, Harvard neuropathologist Matthew Anderson, MD, PhD, and colleagues, report the presence of cellular features consistent with an immune response targeting specialized brain cells in more than two-thirds of autistic brains analyzed postmortem.</span></span></span></span></div>
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<span style="box-sizing: inherit;">These cellular characteristics—not previously observed in autism—lend critical new insight into autism’s origins and could pave the way to improved diagnosis and treatment for people with this disorder.</span></div>
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<span style="box-sizing: inherit;"><span style="color: #1e1e1e;">Read more </span><a href="https://hms.harvard.edu/news/origin-story"><span style="color: red;">here</span></a><span style="color: #1e1e1e;">.</span></span></div>
Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-59658851264263655192019-11-12T15:36:00.000-06:002019-11-12T15:36:25.472-06:00Featured Neuropathologist: Eddie Lee, MD, PhD<table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: right; margin-left: 1em; text-align: right;"><tbody>
<tr><td style="text-align: center;"><a href="http://2.bp.blogspot.com/-LaFBiMllOF0/XcskAq7On2I/AAAAAAAADm4/-uskt_jh1LY7mo-jxj3ZtYG-VXX7F5tOwCK4BGAYYCw/s1600/lee-edward.13094.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" height="320" src="https://2.bp.blogspot.com/-LaFBiMllOF0/XcskAq7On2I/AAAAAAAADm4/-uskt_jh1LY7mo-jxj3ZtYG-VXX7F5tOwCK4BGAYYCw/s320/lee-edward.13094.jpg" width="255" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Edward B. Lee, MD, PhD</td></tr>
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<span style="background-color: white; color: #222222; font-family: "arial" , "tahoma" , "helvetica" , "freesans" , sans-serif; font-size: 13.2px;">From time to time on Neuropathology Blog, we profile a prominent neuropathologist. In the past, we've featured the likes of</span><span style="background-color: white; color: lime; font-family: "arial" , "tahoma" , "helvetica" , "freesans" , sans-serif; font-size: 13.2px;"> </span><a href="http://neuropathologyblog.blogspot.com/2009/09/featured-neuropathologist-craig.html" style="background-color: white; color: orange; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 13.2px; text-decoration-line: none;">Craig Horbinski</a><span style="background-color: white; color: orange; font-family: "arial" , "tahoma" , "helvetica" , "freesans" , sans-serif; font-size: 13.2px;">, </span><a href="http://neuropathologyblog.blogspot.com/2016/06/featured-neuropathologist-roger.html" style="background-color: white; color: orange; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 13.2px; text-decoration-line: none;">Roger McLendon</a><span style="background-color: white; color: orange; font-family: "arial" , "tahoma" , "helvetica" , "freesans" , sans-serif; font-size: 13.2px;">, </span><a href="http://neuropathologyblog.blogspot.com/2009/02/featured-neuropathologist-jan-e-leetsma.html" style="background-color: white; color: orange; font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: 13.2px; text-decoration-line: none;">Jan Leestma</a><span style="font-family: "arial" , "tahoma" , "helvetica" , "freesans" , sans-serif;"><span style="background-color: white; font-size: 13.2px;"><span style="color: orange;">, </span><a href="https://medicine.uiowa.edu/pathology/profile/karra-jones" style="color: orange;">Karra Jones</a><span style="color: orange;">, </span><a href="https://www.youtube.com/watch?v=18WIAOtWMBY" style="color: orange;">Areli Cuevas-Ocampo</a><span style="color: orange;">, </span><a href="https://www.unmc.edu/pathology/faculty/bios/punsoni.html" style="color: orange;">Michael Punsoni</a><span style="color: orange;">, </span>and <a href="http://www.pathology.washington.edu/faculty/cimino" style="color: orange;">PJ Cimino</a>, among others. Today we feature Eddie Lee, MD, PhD. Dr. Lee is an assistant professor in the pathology department at the University of Pennsylvania. </span></span><span style="background-color: white; font-family: arial, tahoma, helvetica, freesans, sans-serif; font-size: 13.2px;">Here's a Q&A with the illustrious Dr. Lee:</span><br />
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<span style="font-family: "arial" , "tahoma" , "helvetica" , "freesans" , sans-serif;"><span style="background-color: white; font-size: 13.2px;"><span style="background: white; color: #1f497d; font-family: "Arial","sans-serif"; font-size: 10.0pt;">1. <i>Why did you decide to become a neuropathologist?</i><o:p></o:p></span></span></span></div>
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<span style="background: white; color: #1f497d; font-family: "Arial","sans-serif"; font-size: 10.0pt;">The three major topics that dominate Alzheimer’s disease
research are amyloid, tau, and neuroinflammation. The discovery of
genetic mutations that cause AD or related dementias, and more recent GWAS
studies support the idea that these three are perhaps the most important
factors that drive AD pathophysiology. However, it is sometimes forgotten
that these were first and foremost neuropathologic observations discovered by
studying human tissues using histology and/or biochemistry by George Glenner
and the McGeers. Genetics came later and was made possible by the
neuropathology. The same can be said regarding TDP-43. This taught
me that neuropathology can be a rock solid foundation for building a research
career. I have always been drawn to basic biomedical research but think
that clinical training provides a sort of “compass” by which you can guide your
research program. To this day, the foundation of my research is
neuropathology because it grounds me towards studying the disease itself.<o:p></o:p></span></div>
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<span style="background: white; color: #1f497d; font-family: "Arial","sans-serif"; font-size: 10.0pt;">2. <i>Name a couple of important professional mentors.
Why were they important to you?<o:p></o:p></i></span></div>
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<span style="background: white; color: #1f497d; font-family: "Arial","sans-serif"; font-size: 10.0pt;">I did my PhD with Virginia Lee at University of
Pennsylvania. She has been doing research for decades together wither her
life partner, John Trojanowski. Together, I saw the two of them
seamlessly integrate neurodegenerative disease neuropathology with basic
science. In terms of neuropathology, I point to many with whom I have been
privileged to train, including Nicholas Gonatas, Bill Schlaepfer, John
Trojanowski, Zissimos Mourelatos, Lucy Rorke-Adams, Jeff Golden and Alex
Judkins. </span><span style="background: white; color: #222222; font-family: "Arial","sans-serif"; font-size: 10.0pt;"><br />
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3. <i>What advice would you give to a pathology resident interested in
doing a neuropathology fellowship?<o:p></o:p></i></span></div>
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<span style="background: white; color: #1f497d; font-family: "Arial","sans-serif"; font-size: 10.0pt;">Get to know what neuropathologists do. There is a wide
variation of career paths available for neuropathologist, and the most
important thing for you to figure out is what kind of neuropathologist you
might want to become. This is key because this should be what is guiding
your choice in neuropathology fellowship. So figure out what your ‘local’
neuropathologist does, and look nationally for what other neuropathologists are
doing. <o:p></o:p></span></div>
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<span style="background: white; color: #1f497d; font-family: "Arial","sans-serif"; font-size: 10.0pt;">For those who are interested in a more basic science track
neuropathology career, here is a historical perspective. Since the
beginning of academic medicine, there has been a tension between the
reductionist approach where medicine is a branch of science (supported by
people like Flexner and Welch) versus a more humanistic approach where medicine
is an art (supported by people like Peabody and Osler). For Peabody and Osler,
clinical observation and pathologic correlation was tantamount. In
contrast, the reductionists thought that “by the end of the [19<sup>th</sup>]
century, clinicopathologic correlation was reaching the limits of its
explanatory possibilities.” I will say that this sentiment is still very
much alive in many corners of biomedical research. I urge you to try to think
mechanistically as much as possible, to strive to understand not only pathology
but pathophysiology.</span><span style="background: white; color: #222222; font-family: "Arial","sans-serif"; font-size: 10.0pt;"><br />
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4. <i>What city would you like a future American Association of
Neuropathologists meeting to be held and why?</i></span><span style="background: white; color: #222222; font-family: "Arial","sans-serif"; font-size: 10.0pt;"><o:p></o:p></span></div>
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<span style="background: white; color: #1f497d; font-family: "Arial","sans-serif"; font-size: 10.0pt;">Interesting question for me as I am currently the Assistant
Secretary Treasurer for AANP and so I help identify and select the AANP meeting
sites. There is a lot that goes into the decision. We have done our
best to maintain a reasonable cost for attendees. There are many sites
that are excluded, often from more popular locations, because the cost for
attendees would be significantly higher not only for AANP but for people
booking rooms. We also look at whether anyone in the US can fly to the
site with at most one layover, whether there are sufficient restaurants close
by, etc. These factors greatly reduce the number of sites that are
possible. I helped pick Monterey, CA for the 2020 meeting for which I am
super psyched. A big question that it would be good to ask everyone is
where to have the 2024 meeting which will be the 100<sup>th</sup> AANP
meeting. We will be choosing the site in the next year or so. One
thought is to go expensive/luxurious (Hawaii anyone?) vs. traditional/historic
(Atlantic City, NJ which is where the original AANP meetings were
held). </span><span style="background: white; color: #222222; font-family: "Arial","sans-serif"; font-size: 10.0pt;"><o:p></o:p></span></div>
</span></span>Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0tag:blogger.com,1999:blog-5424255638293718915.post-91176007565623680052019-11-07T14:51:00.000-06:002019-11-07T14:51:18.302-06:00Forensic neuropathologist featured in AMA’s “Shadow Me” Specialty Series<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto; text-align: center;"><tbody>
<tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-MSQS02X_pf0/XcSB0dP0udI/AAAAAAAADms/MkRdDOq3X1Q12HkRtNoC3zOfVLvjpJWXQCK4BGAYYCw/s1600/2019-08-22-SHADOWME_MICHELLEJORDEN.jpg" imageanchor="1" style="margin-left: auto; margin-right: auto;"><img border="0" src="https://4.bp.blogspot.com/-MSQS02X_pf0/XcSB0dP0udI/AAAAAAAADms/MkRdDOq3X1Q12HkRtNoC3zOfVLvjpJWXQCK4BGAYYCw/s400/2019-08-22-SHADOWME_MICHELLEJORDEN.jpg" /></a></td></tr>
<tr><td class="tr-caption" style="text-align: center;">Michelle Jorden, MD</td></tr>
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<strong><span style="background: white; color: #252525; font-size: 12.0pt; font-weight: normal; line-height: 115%; mso-bidi-font-weight: bold;"><a href="https://www.sccgov.org/sites/coroner/about-us/Pages/staff.aspx">Dr.Michelle Jorden</a></span></strong><strong><span style="background: white; color: #252525; font-size: 12.0pt; line-height: 115%;">, </span></strong><span class="ms-rtefontsize-4"><span style="background: white; color: #252525; font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;">chief
medical examiner for the county of Santa Clara in California, was recently
featured in the American Medical Association's <a href="https://www.ama-assn.org/residents-students/specialty-profiles/what-it-s-specialize-forensic-pathology-shadowing-dr-jorden">"Shadow
Me" Specialty Series</a>. </span></span></div>
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<span style="background: white; color: #252525; font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;"><br />
</span>Dr. Jorden <span style="-webkit-text-stroke-width: 0px; font-variant-caps: normal; font-variant-ligatures: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; widows: 2; word-spacing: 0px;"> </span><span style="-webkit-text-stroke-width: 0px; font-variant-caps: normal; font-variant-ligatures: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; widows: 2; word-spacing: 0px;">has been employed in Santa Clara County since 2008. She obtained her medical
degree from Northwestern, and did her anatomic and neuropathology
training at Stanford. She did her fellowship in forensic pathology at the Cook
County Medical Examiner’s Office in Chicago.</span><span style="font-family: "Times New Roman","serif"; font-size: 12.0pt; line-height: 115%;"><o:p></o:p></span></div>
<br />Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.com0