tag:blogger.com,1999:blog-5424255638293718915.post2356004473247473609..comments2024-03-18T01:10:51.745-05:00Comments on neuropathology blog: MOC Exam Topic: Aquaporin-4Brian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-5424255638293718915.post-87088672195996575742016-11-07T19:42:01.576-06:002016-11-07T19:42:01.576-06:00And one can only get so far without mentioning the...And one can only get so far without mentioning the glymphatic pathway..<br /><br /><i>Genetic knock-out of the gene encoding the astroglial water channel aquaporin-4, which is importantly involved in paravascular interstitial solute clearance, exacerbated glymphatic pathway dysfunction after TBI and promoted the development of neurofibrillary pathology and neurodegeneration in the post-traumatic brain. These findings suggest that chronic impairment of glymphatic pathway function after TBI may be a key factor that renders the post-traumatic brain vulnerable to tau aggregation and the onset of neurodegeneration.</i><br /><br />Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane<br />R, Nedergaard M. Impairment of glymphatic pathway function promotes tau pathology<br />after traumatic brain injury. J Neurosci. 2014 Dec 3;34(49):16180-93.Agent86noreply@blogger.comtag:blogger.com,1999:blog-5424255638293718915.post-52725970876074610432016-11-07T14:16:46.922-06:002016-11-07T14:16:46.922-06:00Worth mentioning that it is the most well known ta...Worth mentioning that it is the most well known target in Neuromyelitis Optica (NMO) and NMO spectrum disorders, since about 80% of patients with this syndrome will have circulating anti-aquaporin 4 antibodies. The IHC is useful when considering active NMOSD on a biopsy specimen by showing loss of staining (Neurology. 2015 Jan 13;84(2):148-58)<br /><br /> Mariahttps://www.blogger.com/profile/13735174077578716213noreply@blogger.com