tag:blogger.com,1999:blog-5424255638293718915.post5279237800454324051..comments2024-03-18T01:10:51.745-05:00Comments on neuropathology blog: "Funny worm-like profiles" in a meningiomaBrian E. Moore, MD, MEdhttp://www.blogger.com/profile/17503916201692804693noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-5424255638293718915.post-77049718202695121262017-09-22T12:17:41.393-05:002017-09-22T12:17:41.393-05:00Interesting insight, Howard. Thank you!Interesting insight, Howard. Thank you!Brian E. Moore, MD, MEdhttps://www.blogger.com/profile/17503916201692804693noreply@blogger.comtag:blogger.com,1999:blog-5424255638293718915.post-72377928538679158582017-09-22T11:26:23.928-05:002017-09-22T11:26:23.928-05:00After seeing similar profiles in the CUSA contents...After seeing similar profiles in the CUSA contents (and only in the CUSA) of several more meningiomas, I am concluding that these are most likely artifacts created by CUSA: Oil droplets created from cell membranes and other lipid membranes during sonication destruction of the cells (by CUSA), with adhering apoptotic nuclei, DNA, and other proteinacious debris on the outside of the oil droplets. Similar oil droplet artifacts may be seen in CUSA contents of other tumors, or hematoma.Howard Changhttps://www.blogger.com/profile/17882009623153232470noreply@blogger.comtag:blogger.com,1999:blog-5424255638293718915.post-1142349006287689552016-04-15T14:40:22.856-05:002016-04-15T14:40:22.856-05:00The unusual profiles are positive for CD34 and vim...The unusual profiles are positive for CD34 and vimentin, but negative for desmin.<br />On behalf of Howard Chang:<br /><br />I am not sure what these results indicate, but negative reactions for GFAP, S100, EMA, and pan-cytokeratin are features that argues against an epithelial or glial-ependymal differentiation. Negative reaction for desmin but positive reactions for vimentin and CD34 suggest mesenchymal but not muscle differentiation. Other thoughts?<br /><br />As I have learned from previous lectures by very smart people, immunohistochemistry reactions color "what I don't know" brown... :(<br /><br />Howard <br />Brian E. Moore, MD, MEdhttps://www.blogger.com/profile/17503916201692804693noreply@blogger.com